Synthetic lipopeptide of six amino acids with a palmitic tail for better penetration. The manufacturer claims stimulation of collagen and glycosaminoglycan synthesis and wrinkle smoothing. Part of well-known anti-age complexes (Matrixyl synthe'6). Belongs to the 'signalling peptide' class.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Signalling peptides as a class show a modest clinical effect in a few RCTs. For Palmitoyl Hexapeptide-12 there are no head-to-head comparisons with retinol or vitamin C in independent studies. The evidence base is primarily manufacturer-led (Sederma) with moderate methodology.
Palmitoyl Hexapeptide-12 is a synthetic lipopeptide of 6 amino acids with a palmitoyl group for penetration. An analog of signaling peptides regulating collagen synthesis. Mechanism. The claimed mechanism is mimicking transforming growth factor-beta (TGF-β), stimulating type I, III collagen and elastin synthesis in fibroblasts. Based on manufacturer in vitro studies. Where applied. Anti-aging serums and creams. Concentration 0.01–0.1% (as part of peptide complexes with matrixyl, argireline, etc.). Evidence base. Independent clinical RCTs are few. No systematic review. CIR has not published a separate assessment. The evidence base is inferior to retinol, vitamin C, glycolic acid. Safety. Hypoallergenic, non-comedogenic. Pregnancy and lactation – topically safe per manufacturers, but no direct data. Unlike palmitoyl pentapeptide-4 (matrixyl), less studied.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Palmitoyl Hexapeptide-12 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Palmitoyl Hexapeptide-12 suits: normal, dry, combination, sensitive.
Synthetic lipopeptide of six amino acids with a palmitic tail for better penetration.
The INCI name is Palmitoyl Hexapeptide-12. It may also appear as: Пальмитоил гексапептид-12.
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