Palmitoyl Hexapeptide-12
Synthetic lipopeptide of six amino acids with a palmitic tail for better penetration. The manufacturer claims stimulation of collagen and glycosaminoglycan synthesis and wrinkle smoothing. Part of well-known anti-age complexes (Matrixyl synthe'6). Belongs to the 'signalling peptide' class.
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Signalling peptides as a class show a modest clinical effect in a few RCTs. For Palmitoyl Hexapeptide-12 there are no head-to-head comparisons with retinol or vitamin C in independent studies. The evidence base is primarily manufacturer-led (Sederma) with moderate methodology.
- Schagen SK. Cosmetics. 2017;4(2):16.
- Sederma. Matrixyl synthe'6 technical documentation. 2013.
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Frequently asked questions
Is Palmitoyl Hexapeptide-12 safe during pregnancy?
Palmitoyl Hexapeptide-12 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Palmitoyl Hexapeptide-12 for?
Palmitoyl Hexapeptide-12 suits: normal, dry, combination, sensitive.