Palmitoyl Tripeptide-5
Peptide mimicking TSP-1 – an activator of latent TGF-β. Stimulates collagen synthesis in vitro. One of the better-studied cosmetic peptides.
Evidence by route
Topical application
Accumulated in vitro data on collagen stimulation. Small human studies show positive effects on wrinkles.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Caution
- Suitable for
- Normal, Dry, Oily, Combination
- Use with caution
- Sensitive
About this ingredient
Palmitoyl Tripeptide-5 (Syn-Coll, Pal-KTTK) is a synthetic lipopeptide: the tripeptide Lys-Val-Lys with palmitic acid. An analog of thrombospondin-1 (TSP-1), which activates TGF-β. Mechanism. Activates latent TGF-β in the dermis, stimulating fibroblasts to synthesize collagen. Claimed effect – rapid collagen stimulation (4–6 weeks), comparable to matrixyl. Where applied. Anti-aging serums and creams. Concentration 2–5 ppm. In Mesoestetic, Skeyndor, Sesderma. Evidence base. DSM, the manufacturer, has published double-blind studies. Independent RCTs are virtually absent. CIR confirmed safety. Safety. Hypoallergenic, non-comedogenic, does not photosensitize. Pregnancy and lactation – use with caution. TGF-β activation is theoretically undesirable in pregnancy (TGF-β participates in placental processes), although topical systemic absorption is minimal. Manufacturers recommend avoidance.
Frequently asked questions
Is Palmitoyl Tripeptide-5 safe during pregnancy?
Palmitoyl Tripeptide-5 should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Palmitoyl Tripeptide-5 for?
Palmitoyl Tripeptide-5 suits: normal, dry, oily, combination. Use with caution in: sensitive.
What is Palmitoyl Tripeptide-5 and what does it do in cosmetics?
Peptide mimicking TSP-1 – an activator of latent TGF-β.
What's the INCI name for Palmitoyl Tripeptide-5?
The INCI name is Palmitoyl Tripeptide-5. It may also appear as: Syn-Coll.
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