Matrixyl (Palmitoyl Pentapeptide-4)
INCI: Palmitoyl Pentapeptide-4
Synthetic peptide mimicking a type I collagen fragment. Activates synthesis of collagen, fibronectin, and hyaluronic acid via dermal cell signaling pathways.
Evidence by route
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Data from two small sponsor-conducted clinical studies demonstrate wrinkle reduction and improved skin firmness. Independent RCTs are absent. In vitro data confirm collagenogenesis stimulation. Actual peptide penetration through the stratum corneum remains debated.
- Robinson LR et al. Int J Cosmet Sci. 2005;27(3):185-195.
Working concentrations
0.005–0.01% (as active peptide)
Tolerability and safety
Irritation potential
LowAllergen risk
LowPregnancy
UnknownSkin types
Suitable for
Frequently asked questions
Is Matrixyl (Palmitoyl Pentapeptide-4) safe during pregnancy?
Safety data for Matrixyl (Palmitoyl Pentapeptide-4) during pregnancy is insufficient. Best avoided when in doubt.
What skin types is Matrixyl (Palmitoyl Pentapeptide-4) for?
Matrixyl (Palmitoyl Pentapeptide-4) suits: normal, dry, sensitive, combination.