Hexapeptide-9
Marketing hexapeptide with claimed effect on collagen synthesis. Evidence base is predominantly manufacturer-sponsored.
Evidence by route
Topical application
Independent RCTs are essentially absent.
How to read tiers A–F
- DNo data, or very weak or conflicting data
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Caution
- Suitable for
- Normal, Dry, Oily, Combination
- Use with caution
- Sensitive
About this ingredient
Hexapeptide-9 (Collaxyl) is a marketing hexapeptide from Vincience (now part of Ashland) with claimed effect on type IV collagen synthesis. Where applied. Anti-aging serums and creams (0.5-3% commercial complex). Evidence base. Manufacturer cites 28-day studies in 20 volunteers – improved firmness and elasticity. No independent peer-reviewed RCTs. The evidence base is predominantly manufacturer-sponsored. Safety. CIR has not made a separate assessment. Pregnancy – use with caution (UNKNOWN). Lactation – safe per manufacturer, no direct data.
Frequently asked questions
Is Hexapeptide-9 safe during pregnancy?
Hexapeptide-9 should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Hexapeptide-9 for?
Hexapeptide-9 suits: normal, dry, oily, combination. Use with caution in: sensitive.
What is Hexapeptide-9 and what does it do in cosmetics?
Marketing hexapeptide with claimed effect on collagen synthesis.
What's the INCI name for Hexapeptide-9?
The INCI name is Hexapeptide-9. It may also appear as: Collaxyl.
See Hexapeptide-9 in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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