Acetyl Tetrapeptide-40
A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Evidence by route
Topical application
A synthetic peptide. Well tolerated; independent data limited.
- CIR Cosmetic Ingredient Review safety assessment
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Normal, Dry, Combination, Oily, Sensitive
About this ingredient
Acetyl Tetrapeptide-40 (INCI Acetyl Tetrapeptide-40) is a short synthetic peptide of four amino acids with an acetyl protection. It is added to anti-ageing products where, by the supplier's intent, it is meant to support firmness and skin renewal. On efficacy I will be direct. There is little data on it, almost all of it from the raw-material maker, with few independent clinical studies. This is a supporting ingredient, not a proven standalone active. In a formula it works as an extra element of care, but it should not earn inflated expectations. During pregnancy and breastfeeding it can be used. The peptide is large, it is not absorbed through the skin systemically when applied topically, and there is no reason for caution. Tolerance is good. The irritation potential is low, the allergy risk is low, and the ingredient suits sensitive skin. Short synthetic peptides are usually neutral and do not provoke reactions.
Frequently asked questions
Is Acetyl Tetrapeptide-40 safe during pregnancy?
Acetyl Tetrapeptide-40 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Acetyl Tetrapeptide-40 for?
Acetyl Tetrapeptide-40 suits: normal, dry, combination, oily, sensitive.
What is Acetyl Tetrapeptide-40 and what does it do in cosmetics?
A synthetic peptide.
What's the INCI name for Acetyl Tetrapeptide-40?
The INCI name is Acetyl Tetrapeptide-40.
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