A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; independent data limited.
Acetyl Tetrapeptide-40 (INCI Acetyl Tetrapeptide-40) is a short synthetic peptide of four amino acids with an acetyl protection. It is added to anti-ageing products where, by the supplier's intent, it is meant to support firmness and skin renewal. On efficacy I will be direct. There is little data on it, almost all of it from the raw-material maker, with few independent clinical studies. This is a supporting ingredient, not a proven standalone active. In a formula it works as an extra element of care, but it should not earn inflated expectations. During pregnancy and breastfeeding it can be used. The peptide is large, it is not absorbed through the skin systemically when applied topically, and there is no reason for caution. Tolerance is good. The irritation potential is low, the allergy risk is low, and the ingredient suits sensitive skin. Short synthetic peptides are usually neutral and do not provoke reactions.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl Tetrapeptide-40 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Tetrapeptide-40 suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Acetyl Tetrapeptide-40. It may also appear as: Ацетил тетрапептид-40.
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