Acetylated 4-amino-acid peptide – an anti-glycation and anti-puffiness component. Used in products against eye puffiness and dark circles. Pregnancy-safe.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Anti-AGE peptide for the eye area. Moderate evidence.
Acetyl Tetrapeptide-5 (Eyeseryl) is a synthetic acetylated tetrapeptide. INCI: Acetyl Tetrapeptide-5. Developed by Lipotec to reduce puffiness and dark circles around the eyes. In cosmetics it works through several mechanisms: blocks collagen glycation (anti-AGEs), improves lymph drainage, reduces capillary permeability. The manufacturer reports a 17% reduction in visible eye bags after 28 days. Use levels run from 1 to 10% of the commercial solution (containing about 0.05% peptide). Pregnancy safety. Systemic absorption is minimal. Skin profile. Low irritation and allergen potential. Non-comedogenic. Suitable for all skin types. Moderate evidence (B).
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl Tetrapeptide-5 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Tetrapeptide-5 suits: normal, dry, combination, oily, sensitive.
Acetylated 4-amino-acid peptide – an anti-glycation and anti-puffiness component.
On the Fulton scale 0/5 – non-comedogenic. For acne-prone skin, a rating of 3 or higher suggests choosing an alternative.
The INCI name is Acetyl Tetrapeptide-5. It may also appear as: Eyeseryl, ацетил тетрапептид-5.
Published: · updated: