A synthetic peptide. The maker links it to firmness and skin renewal; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A synthetic peptide. Well tolerated; independent data limited.
Acetyl sh-hexapeptide-5 amide acetate (INCI: Acetyl sh-Hexapeptide-5 Amide Acetate) is a short-chain synthetic peptide. In a formula it is added as a signalling ingredient, and makers link it to firmness and skin renewal. It is worth tempering expectations. The case rests mainly on supplier data, while independent confirmation of clear clinical effects stays thin. We place it as a supporting active with a modest base, not a proven peptide. It may add value inside a formula but does not by itself guarantee a visible change. In topical use peptides of this size barely penetrate to a systemic level, so it can be used during pregnancy and breastfeeding without any foreseeable risk. Tolerance is good, with low irritation and allergy potential, suitable for sensitive skin. Reactions to synthetic peptides are uncommon.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl sh-Hexapeptide-5 Amide Acetate is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl sh-Hexapeptide-5 Amide Acetate suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Acetyl sh-Hexapeptide-5 Amide Acetate. It may also appear as: Ацетил sh-гексапептид-5 амид ацетат.
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