Peptide with potential stimulation of thymus-driven epidermal renewal. Features in formulas against tone loss and tired skin.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Data stays limited to manufacturer marketing research. Independent controlled clinical work remains scarce.
Acetyl Tetrapeptide-2 (trade name Uplevity / Thymulen-4 by Sederma) is a synthetic tetrapeptide with an N-acetyl group. Structure models a thymic peptide that regulates immunity and epidermal proliferation. Claimed mechanism. The manufacturer reports thymus-like activity in skin: increased keratinocyte proliferation, synthesis of type IV and VII collagen in the basement membrane, and fibrillin-1. Thymic activity declines with age, giving rise to a 'mature-skin renewal' marketing rationale. Where applied. Anti-aging serums and creams for 40+ skin (2–5%). Often combined with Matrixyl peptides, retinol, niacinamide. Brands: Sesderma Mesoses, Skeyndor Power Hyaluronic, Cremorlab. Evidence base. Manufacturer in vitro data – type IV collagen synthesis up to +67%. No independent RCTs with clinical endpoints. Safety. Hypoallergenic, non-irritating, non-comedogenic. Topical systemic absorption is minimal. Pregnancy and lactation – no data. As a precaution, in pregnancy choose peptides with a better-studied profile (Matrixyl 3000) or gentler alternatives (adenosine, niacinamide). Realistic take. Weak independent evidence but a safe profile. Used as part of a multi-active serum, not on its own.
Irritation potential
LowAllergen risk
LowPregnancy
UnknownSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Safety data for Acetyl Tetrapeptide-2 during pregnancy is insufficient. Best avoided when in doubt.
Acetyl Tetrapeptide-2 suits: normal, dry, oily, combination, sensitive.
Peptide with potential stimulation of thymus-driven epidermal renewal.
The INCI name is Acetyl Tetrapeptide-2.
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