Hexapeptide-11
Yeast-derived peptide studied for effects on cellular senescence (in vitro). Functional formulation ingredient with no standalone activity on the skin.
Evidence by route
Topical application
Inert formulation ingredient. Safe, no standalone activity.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
About this ingredient
Hexapeptide-11 is a yeast-derived hexapeptide of 6 amino acids isolated from an enzymatic hydrolysate of Saccharomyces cerevisiae. Marketed as an "anti-senescence" peptide. Where applied. Anti-aging serums, mature skin creams (0.5-3% commercial complex). Common in premium formulas. Evidence base. In vitro work in fibroblast cultures (Tan 2014): cellular senescence reduction by 25-40% over 6 days. Almost no clinical RCTs of topical use. Marketing outpaces the evidence base. Safety. CIR has not made a separate assessment. Contact reactions are rare at standard cosmetic concentrations. Pregnancy – safe. Lactation – no data.
Frequently asked questions
Is Hexapeptide-11 safe during pregnancy?
Hexapeptide-11 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What is Hexapeptide-11 and what does it do in cosmetics?
Yeast-derived peptide studied for effects on cellular senescence (in vitro).
What's the INCI name for Hexapeptide-11?
The INCI name is Hexapeptide-11.
See Hexapeptide-11 in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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