Acetyl Hexapeptide-37
Updated version of the Argireline peptide. Marketing promises a reduction of expression wrinkles «like botox», but clinical effects are much more modest.
Evidence by route
Topical application
The peptide is too large for effective penetration through the stratum corneum. Manufacturer studies show slight relief smoothing; independent RCTs reproduce the result poorly.
How to read tiers A–F
- DNo data, or very weak or conflicting data
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Unknown
- Suitable for
- Oily, Dry, Combination, Normal
About this ingredient
Acetyl Hexapeptide-37 (trade name Argireline XL by Lipotec) is an updated version of classic Argireline (Acetyl Hexapeptide-8). The manufacturer claims improved SNAP-25 affinity and a longer-lasting effect. Claimed mechanism. Like its predecessor – competes with endogenous SNAP-25 for SNARE-complex assembly at the presynaptic neuromuscular membrane. Theoretically blocks acetylcholine release and facial muscle contraction. In practice, efficacy is limited by poor epidermal penetration of large peptides. Where applied. Anti-aging serums and creams for expression lines (5–10%). Brands: Sesderma Fillderma Lips, Mesoestetic Stem Cell Active, Martiderm. Evidence base. Manufacturer marketing claims up to 30% wrinkle depth reduction in 28 days. No independent clinical RCTs with endpoints. By extrapolation from Argireline (AHA-8), the effect is modest and substantially weaker than botulinum therapy. Safety. Hypoallergenic, non-irritating, non-comedogenic. Topical systemic absorption is minimal. Pregnancy and lactation – no data. Spanish gynecologists (SEGO 2023) recommend avoiding 'botox-mimic' actives in pregnancy as a precaution. Realistic take. A marketing iteration of Argireline. Not 'botox in a jar'. Use as part of a multi-active anti-aging serum, not alone.
Frequently asked questions
Is Acetyl Hexapeptide-37 safe during pregnancy?
Safety data for Acetyl Hexapeptide-37 during pregnancy is insufficient. Best avoided when in doubt.
What skin types is Acetyl Hexapeptide-37 for?
Acetyl Hexapeptide-37 suits: oily, dry, combination, normal.
What is Acetyl Hexapeptide-37 and what does it do in cosmetics?
Updated version of the Argireline peptide.
What's the INCI name for Acetyl Hexapeptide-37?
The INCI name is Acetyl Hexapeptide-37. It may also appear as: Argireline XL.
See Acetyl Hexapeptide-37 in a product composition right on the store page
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
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