Bee Venom
INCI: Apis Mellifera Venom
Honeybee venom containing melittin, phospholipase A2, and apamin. In Korean cosmetics it is marketed as a 'natural Botox' – supposedly triggering micro-contraction of facial muscles. In reality, local irritation activates micro-circulation and causes temporary skin tightening. Contraindicated in bee or insect-sting allergy. No clinically meaningful anti-age effect shown in independent studies.
Evidence by route
Topical application
DVery weak or conflicting data.
A few small Korean RCTs showed modest effects on wrinkles and acne. Methodological quality is low. The main risk is anaphylaxis in patients with bee allergy. The 'Botox alternative' marketing claim does not match the actual mechanism.
- Han SM et al. Clin Exp Dermatol. 2013;38(8):926-932.
Tolerability and safety
Irritation potential
HighAllergen risk
HighPregnancy
AvoidSkin types
Use with caution
Frequently asked questions
Is Bee Venom safe during pregnancy?
Bee Venom is not recommended during pregnancy. Consider an alternative from the same category.
What skin types is Bee Venom for?
Use with caution in: normal, dry, combination, oily, sensitive.
Can Bee Venom irritate the skin?
Yes, Bee Venom has high irritation potential. Start at low concentrations, introduce gradually, and always use SPF during the day.
Can Bee Venom cause an allergic reaction?
Bee Venom has high allergen potential. Perform a patch test on the inner forearm 24 hours before facial application.