A synthetic peptide. The maker links it to reduced skin sensitivity; independent data are limited. Well tolerated.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
A peptide. Well tolerated; independent data limited.
Acetyl Tetrapeptide-15 (INCI: Acetyl Tetrapeptide-15) is a synthetic peptide of four amino acids with an acetyl group. The manufacturer links it to reduced skin reactivity, with the idea of modulating the signals that drive a feeling of discomfort or itch. It appears in serums and creams for sensitive skin. On efficacy, caution is in order. Independent evidence is scarce and most data come from the supplier, so it is better seen as a promising supporting active rather than a proven treatment. It may add comfort within a good formula, with no guarantee of a strong effect on its own. For topical use it has no systemic relevance and can be used during pregnancy and breastfeeding. Tolerance is good: low irritation potential and low allergy risk, suitable for sensitive skin, which is its target audience.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to iHerb, Sephora, Druni and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Acetyl Tetrapeptide-15 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Acetyl Tetrapeptide-15 suits: normal, dry, combination, oily, sensitive.
A synthetic peptide.
The INCI name is Acetyl Tetrapeptide-15. It may also appear as: Ацетил тетрапептид-15.
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