Active component of licorice root. Anti-inflammatory effect supported by RCTs in atopic dermatitis and rosacea.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Anti-inflammatory ingredient with genuine evidence base. Mild effect, safe for long-term use. Works well in soothing formulas.
Glycyrrhetinic acid (18-beta-glycyrrhetinic acid, Enoxolone) is a triterpenoid acid, the active component of licorice root. Formed by hydrolysis of glycyrrhizin – the main licorice saponin. Mechanism. Anti-inflammatory effect via inhibition of 11-beta-hydroxysteroid dehydrogenase – suppresses degradation of endogenous cortisol in the skin, extending its anti-inflammatory action. Additionally suppresses PGE2, COX-2, TNF-alpha. Where applied. Repair and soothing products, formulas for rosacea, atopic dermatitis, post-procedure skin (0.1-2%). In Spain in La Roche-Posay Toleriane, Bioderma Sensibio, Avène Cicalfate. Evidence base. Saeedi 2003 in an RCT in 60 atopic dermatitis patients showed that a 2% glycyrrhetinic acid cream over 2 weeks reduced erythema and itching comparably to 1% topical hydrocortisone. Not as potent as topical steroids but without long-term adverse effects (skin atrophy, perioral dermatitis). Safety. CIR confirmed safety. Hypoallergenic, non-comedogenic. Some patients may have rare contact reactions. Pregnancy – safe topically at cosmetic concentrations (topical absorption of systemic glycyrrhizin is minimal). Lactation – no data; avoid use on nipple areas as a precaution.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Glycyrrhetinic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Glycyrrhetinic Acid suits: normal, dry, oily, combination, sensitive.
Active component of licorice root.
The INCI name is Glycyrrhetinic Acid. It may also appear as: 18-beta-Glycyrrhetinic Acid, Enoxolone.
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