Cutibacterium Granulosum Ferment Extract Filtrate

Evidence by route

About this ingredient

Cutibacterium Granulosum Ferment Extract Filtrate is a filtrate lysate of the skin commensal bacterium Cutibacterium granulosum. One of the newer probiotic ingredients in cosmetics, developed in the 'microbiome-friendly' care concept. Mechanism. The lysate contains bacterial cell wall components (peptidoglycan, teichoic acids) that, on topical application, modulate the skin immune response – activating toll-like receptors and supporting balance between pro- and anti-inflammatory signals. Manufacturers market it as 'training' the microbiome and supporting barrier function. Where applied. Pre/post-biotic line serums and creams, products for sensitive skin and compromised barrier, microbiome-approach anti-acne products. In Spain – Aurelia London, Esse Probiotic Skincare, niche brands with microbiome focus. Evidence base. Clinical data are preliminary. Specific literature on Cutibacterium granulosum in cosmetics is scarce – most skin microbiome research focuses on other strains (Cutibacterium acnes, Staphylococcus epidermidis, Lactobacillus). Skin efficacy in patient RCTs is not confirmed. Safety. CIR has not issued a direct evaluation. As a lysate of a commensal bacterium, the safety profile is normal. Allergic reactions are theoretically possible in patients with severe atopy, rare in practice. Pregnancy and lactation – insufficient data. Manufacturers recommend caution, especially in the first trimester. Best suited to: sensitive skin, compromised skin barrier, acne-prone skin within a microbiome-oriented program. Not a first-line active – the evidence base is still forming.

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