Lysate of a skin commensal bacterium studied as a skin-microbiome probiotic; clinical data preliminary.
Topical application
CWeak evidence. In vitro data, open-label studies, or expert consensus.
Plant extract. Clinically meaningful effect on human skin is not supported by robust evidence; data limited to in vitro / lab models.
Cutibacterium Granulosum Ferment Extract Filtrate is a filtrate lysate of the skin commensal bacterium Cutibacterium granulosum. One of the newer probiotic ingredients in cosmetics, developed in the 'microbiome-friendly' care concept. Mechanism. The lysate contains bacterial cell wall components (peptidoglycan, teichoic acids) that, on topical application, modulate the skin immune response – activating toll-like receptors and supporting balance between pro- and anti-inflammatory signals. Manufacturers market it as 'training' the microbiome and supporting barrier function. Where applied. Pre/post-biotic line serums and creams, products for sensitive skin and compromised barrier, microbiome-approach anti-acne products. In Spain – Aurelia London, Esse Probiotic Skincare, niche brands with microbiome focus. Evidence base. Clinical data are preliminary. Specific literature on Cutibacterium granulosum in cosmetics is scarce – most skin microbiome research focuses on other strains (Cutibacterium acnes, Staphylococcus epidermidis, Lactobacillus). Skin efficacy in patient RCTs is not confirmed. Safety. CIR has not issued a direct evaluation. As a lysate of a commensal bacterium, the safety profile is normal. Allergic reactions are theoretically possible in patients with severe atopy, rare in practice. Pregnancy and lactation – insufficient data. Manufacturers recommend caution, especially in the first trimester. Best suited to: sensitive skin, compromised skin barrier, acne-prone skin within a microbiome-oriented program. Not a first-line active – the evidence base is still forming.
Irritation potential
LowAllergen risk
LowPregnancy
UnknownThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Safety data for Cutibacterium Granulosum Ferment Extract Filtrate during pregnancy is insufficient. Best avoided when in doubt.
Lysate of a skin commensal bacterium studied as a skin-microbiome probiotic; clinical data preliminary.
The INCI name is Cutibacterium Granulosum Ferment Extract Filtrate. It may also appear as: Cutibacterium granulosum ферментный фильтрат.
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