Beta-Glucan
Polysaccharide from yeast, fungal, or oat cell walls. An immunomodulator and humectant that stimulates macrophages and accelerates wound healing.
Evidence by route
Topical application
Small clinical studies show anti-inflammatory effects, improved wound healing, and skin hydration. Immunostimulatory properties are well documented in vitro. No large dermatological RCTs.
- Beta-glucan-based cream (containing pleuran isolated from Pleurotus ostreatus) in supportive treatment of mild-to-moderate atopic dermatitis. J Dermatolog Treat. 2016;27(4):373-379.. PMID 26654776
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Sensitive, Dry, Normal, Combination
About this ingredient
Beta-Glucan is a natural polysaccharide from the cell walls of yeast (Saccharomyces cerevisiae), fungi (reishi, shiitake), and cereals (oats, barley). Topical cosmetics most often use yeast beta-glucan with a branched 1,3/1,6 structure – the most studied. Mechanism. Binds dectin-1 on the membrane of keratinocytes and Langerhans cells, triggering a mild immunomodulatory signal. In wounds it accelerates fibroblast and keratinocyte migration, stimulates collagen synthesis, and TGF-β. In parallel it works as a humectant: the high molecular weight branched structure holds water in the stratum corneum. Where applied. Post-procedure repair serums and creams, sensitive-skin and rosacea products, anti-age formulas. Concentration 0.1–1%. In Spain part of Sesderma Reti-Age, Mesoestetic Hydra-Vital Factor K, Endocare Tensage. K-beauty lines (Purito, COSRX) often build formulas around 0.5–1% beta-glucan. Evidence base. Pillai 2005 (n=27) showed improved hydration and reduced wrinkle depth with 0.1% yeast β-glucan over 8 weeks. Du 2014 (review) summarised data on faster wound healing and anti-inflammatory activity. Majtan 2013 described use in wound dressings with positive effect. For anti-age the evidence is moderate – below retinoids and vitamin C, but real. Safety. CIR confirmed safety of yeast and oat β-glucan. Hypoallergenic, non-comedogenic, non-irritating. In some patients with oat or yeast allergy isolated reactions occur – rare. Pregnancy and lactation – safe topically. Used without restriction. One of the few good anti-age actives in pregnancy alongside niacinamide and azelaic acid. Particularly suitable for. Sensitive and reactive skin, rosacea, post-procedure recovery (after laser, peels, injections), post-acne recovery, anti-age in pregnancy and lactation, in patients who do not tolerate retinoids. Often combined with panthenol, hyaluronic acid, niacinamide, allantoin, and centella extract.
Frequently asked questions
Is Beta-Glucan safe during pregnancy?
Beta-Glucan is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Beta-Glucan for?
Beta-Glucan suits: sensitive, dry, normal, combination.
What is Beta-Glucan and what does it do in cosmetics?
Polysaccharide from yeast, fungal, or oat cell walls.
What's the INCI name for Beta-Glucan?
The INCI name is Beta-Glucan. It may also appear as: Avena Sativa Beta Glucan.
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