Beta-Glucan

Evidence by route

About this ingredient

Beta-Glucan is a natural polysaccharide from the cell walls of yeast (Saccharomyces cerevisiae), fungi (reishi, shiitake), and cereals (oats, barley). Topical cosmetics most often use yeast beta-glucan with a branched 1,3/1,6 structure – the most studied. Mechanism. Binds dectin-1 on the membrane of keratinocytes and Langerhans cells, triggering a mild immunomodulatory signal. In wounds it accelerates fibroblast and keratinocyte migration, stimulates collagen synthesis, and TGF-β. In parallel it works as a humectant: the high molecular weight branched structure holds water in the stratum corneum. Where applied. Post-procedure repair serums and creams, sensitive-skin and rosacea products, anti-age formulas. Concentration 0.1–1%. In Spain part of Sesderma Reti-Age, Mesoestetic Hydra-Vital Factor K, Endocare Tensage. K-beauty lines (Purito, COSRX) often build formulas around 0.5–1% beta-glucan. Evidence base. Pillai 2005 (n=27) showed improved hydration and reduced wrinkle depth with 0.1% yeast β-glucan over 8 weeks. Du 2014 (review) summarised data on faster wound healing and anti-inflammatory activity. Majtan 2013 described use in wound dressings with positive effect. For anti-age the evidence is moderate – below retinoids and vitamin C, but real. Safety. CIR confirmed safety of yeast and oat β-glucan. Hypoallergenic, non-comedogenic, non-irritating. In some patients with oat or yeast allergy isolated reactions occur – rare. Pregnancy and lactation – safe topically. Used without restriction. One of the few good anti-age actives in pregnancy alongside niacinamide and azelaic acid. Particularly suitable for. Sensitive and reactive skin, rosacea, post-procedure recovery (after laser, peels, injections), post-acne recovery, anti-age in pregnancy and lactation, in patients who do not tolerate retinoids. Often combined with panthenol, hyaluronic acid, niacinamide, allantoin, and centella extract.

Tolerability and safety

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