Madecassoside
The primary triterpenic glycoside from Centella asiatica. Suppresses inflammation and stimulates type I collagen synthesis. More standardized than raw centella extract.
Evidence by route
Topical application
Small clinical studies show anti-inflammatory effects and accelerated healing. Collagenogenesis stimulation confirmed in vitro. The advantage over raw centella extract is dose reproducibility.
- Bylka W et al. Postepy Dermatol Alergol. 2014;31(1):46-49. PMID 24278045
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Safe
- Suitable for
- Sensitive, Dry, Normal, Combination
About this ingredient
Madecassoside is a triterpenoid glycoside of Centella asiatica, the most studied of the four key TECA-complex components (madecassoside, madecassic acid, asiaticoside, asiatic acid). Structurally it is madecassic acid with an attached sugar, which increases water solubility. Mechanism. Stimulates fibroblast proliferation and type I and III collagen synthesis via TGF-β signaling (Bonté 1994). Suppresses pro-inflammatory cytokines (IL-1β, TNF-α, IL-6) and NF-κB activation. Antioxidant effect via reactive oxygen species neutralization. Accelerates wound healing and epithelialization. Where applied. Post-procedure serums and creams, atopy and rosacea products, repair creams. Concentration 0.1–1%. In Spain in La Roche-Posay Cicaplast, Bioderma Cicabio, Avène Cicalfate, Endocare Cellage Day Prodermis. Often combined with panthenol, niacinamide, ceramides. Evidence base. Hong 2008 clinical study in 60 photoaged patients showed 18% reduction in wrinkle depth over 12 weeks at 0.2%. Bylka 2014 meta-analysis confirmed efficacy of centella extracts (with madecassoside) for wounds, burns, scars. CIR confirmed safety. Safety. Hypoallergenic at cosmetic concentrations, non-comedogenic, does not photosensitize. Allergic reactions are rare (1–3% in eczema and Asteraceae pollinosis patients). Pregnancy and lactation – use with caution. Topical use at 0.1–1% is rated conditionally acceptable. Direct pregnancy data are limited. Oral centella in supplement doses is contraindicated (possible estrogen-like activity). Alternatives – adenosine, panthenol, niacinamide. Who it suits. Sensitive skin, rosacea, post-acne marks, atopic dermatitis, recovery after laser, chemical peels, microneedling. Often combined with panthenol and ceramides for synergistic barrier repair.
Frequently asked questions
Is Madecassoside safe during pregnancy?
Madecassoside is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Madecassoside for?
Madecassoside suits: sensitive, dry, normal, combination.
What is Madecassoside and what does it do in cosmetics?
The primary triterpenic glycoside from Centella asiatica.
What's the INCI name for Madecassoside?
The INCI name is Madecassoside.
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