Benzoyl Peroxide

Antibacterial agent that kills C. acnes by generating oxygen free radicals. Does not induce antibiotic resistance – a key advantage over antibiotics.

Acne

Evidence by route

Topical application

Proven efficacy. Two or more independent RCTs with instrumental endpoints.

One of the most studied acne treatments. Meta-analyses confirm reduction of inflammatory and non-inflammatory lesions. Combination with adapalene (Epiduo) provides synergistic effect. FDA approved as OTC.

Yang Z et al. Int J Dermatol. 2020;59(2):169-183.
Leyden JJ et al. J Am Acad Dermatol. 2001;45(2):187-195.

Working concentrations

2.5–10% (2.5% works as well as 10% with less irritation)

Tolerability and safety

Irritation potential

High

Allergen risk

Moderate

Pregnancy

Caution

For sensitive skin

Dries the skin and may cause peeling. Contact allergy develops in 1–2% of patients. Bleaches fabrics and hair.

Skin types

Suitable for

OilyCombination

Use with caution

SensitiveDry

Combinations with other ingredients

Does not combine with

RetinolРетинол

Benzoyl peroxide oxidizes retinol, inactivating it. When both are needed – use at different times: BPO in morning, retinol at night.

TretinoinТретиноин

Classic incompatibility: BPO oxidizes tretinoin. Exceptions: micronized clindamycin+BPO (Duac) and adapalene+BPO (Epiduo) where formulation stability is engineered.

L-Ascorbic Acid (Vitamin C)L-Аскорбиновая кислота (витамин C)

BPO oxidizes ascorbic acid, inactivating it. Use at different times of day.

Frequently asked questions

Is Benzoyl Peroxide safe during pregnancy?

Benzoyl Peroxide should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.

What skin types is Benzoyl Peroxide for?

Benzoyl Peroxide suits: oily, combination. Use with caution in: sensitive, dry.

Can Benzoyl Peroxide irritate the skin?

Yes, Benzoyl Peroxide has high irritation potential. Start at low concentrations, introduce gradually, and always use SPF during the day.