Adapalene
Third-generation synthetic retinoid. Photostable, less irritating than tretinoin. Available OTC at 0.1% concentration (Differin).
Evidence by route
Topical application
AProven efficacy. Two or more independent RCTs with instrumental endpoints.
Meta-analyses confirm acne efficacy comparable to tretinoin with better tolerability. FDA approved 0.1% as OTC acne treatment. Less photoaging evidence than tretinoin, but studies show anti-aging potential.
- Shalita AR et al. J Am Acad Dermatol. 1996;34(3):482-485.
- Thiboutot DM et al. J Am Acad Dermatol. 2008;59(4):541-546.
Working concentrations
0.1–0.3%
Tolerability and safety
Irritation potential
MediumAllergen risk
LowPregnancy
AvoidSkin types
Suitable for
Use with caution
Frequently asked questions
Is Adapalene safe during pregnancy?
Adapalene is not recommended during pregnancy. Consider an alternative from the same category.
What skin types is Adapalene for?
Adapalene suits: oily, combination, normal. Use with caution in: sensitive, dry.
Can Adapalene irritate the skin?
Adapalene has moderate irritation potential. Sensitive skin may show a transient reaction that usually settles with adaptation.