Tretinoin

Retinoic acid – the most active topical form of vitamin A. A prescription drug and the gold standard for topical anti-aging and acne treatment.

Anti-agingAcneBrightening

Evidence by route

Topical application

Proven efficacy. Two or more independent RCTs with instrumental endpoints.

Dozens of RCTs and meta-analyses confirm efficacy for photoaging, acne, and hyperpigmentation. Increases collagen synthesis, accelerates cell turnover, and normalizes desquamation. FDA-approved for acne and photodamage.

Mukherjee S et al. Clin Interv Aging. 2006;1(4):327-348.
Leyden JJ et al. J Am Acad Dermatol. 2017;76(6):AB4.

Working concentrations

0.025–0.1% (prescription drug)

How to introduce

Start at 0.025% every other day, gradually transitioning to daily use. Adaptation takes 6–12 weeks.

Tolerability and safety

Irritation potential

High

Allergen risk

Low

Pregnancy

Avoid

For sensitive skin

Retinoid dermatitis (peeling, redness, burning) is a normal adaptation response. Short-contact method (apply for 30 min, then rinse) helps reduce irritation.

Skin types

Suitable for

NormalCombinationOily

Use with caution

SensitiveDry

Combinations with other ingredients

Works well with

Azelaic AcidАзелаиновая кислота

Used by dermatologists for melasma and acne. Tretinoin accelerates turnover, azelaic acid reduces pigmentation and inflammation.

Does not combine with

Benzoyl PeroxideБензоилпероксид

Classic incompatibility: BPO oxidizes tretinoin. Exceptions: micronized clindamycin+BPO (Duac) and adapalene+BPO (Epiduo) where formulation stability is engineered.

Frequently asked questions

Is Tretinoin safe during pregnancy?

Tretinoin is not recommended during pregnancy. Consider an alternative from the same category.

What skin types is Tretinoin for?

Tretinoin suits: normal, combination, oily. Use with caution in: sensitive, dry.

Can Tretinoin irritate the skin?

Yes, Tretinoin has high irritation potential. Start at low concentrations, introduce gradually, and always use SPF during the day.