Tranexamic Acid

Synthetic lysine derivative. Suppresses plasminogen activation in keratinocytes, reducing prostaglandin synthesis and melanocyte activity.

Brightening

Evidence by route

Topical application

Weak evidence. In vitro data, open-label studies, or expert consensus.

Small RCTs show improvement in melasma with 2–5% tranexamic acid. Effect is weaker than the oral route. Independent large studies are limited.

Ebrahimi B et al. J Res Med Sci. 2014;19(8):753-757.

Oral intake

Limited evidence. One RCT or several controlled studies with limitations.

Oral tranexamic acid is one of the most evidence-based treatments for melasma. A 2020 meta-analysis of 10 RCTs confirmed significant reductions in MASI and mMASI indices. Risk of thrombosis with prolonged use requires assessment in at-risk patients.

Li Y et al. J Dermatol. 2021;48(3):291-298.
Colferai MMT et al. J Cosmet Dermatol. 2019;18(6):1583-1589.

Working concentrations

2–5% topically; 500–750 mg/day orally (prescription only)

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Unknown

Skin types

Suitable for

NormalDrySensitiveCombinationOily

Combinations with other ingredients

Works well with

NiacinamideНиацинамид

Synergy for melasma: tranexamic acid suppresses tyrosinase, niacinamide blocks melanosome transfer to keratinocytes.

Frequently asked questions

Is Tranexamic Acid safe during pregnancy?

Safety data for Tranexamic Acid during pregnancy is insufficient. Best avoided when in doubt.

What skin types is Tranexamic Acid for?

Tranexamic Acid suits: normal, dry, sensitive, combination, oily.