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Hyaluronic Acid

INCI: Sodium Hyaluronate

Natural polysaccharide that binds water up to 1000 times its own weight. Topical application creates a surface humectant effect without dermal penetration.

Moisturizing

Evidence by route

Topical application

C

Weak evidence. In vitro data, open-label studies, or expert consensus.

Surface humectant effect is well established. Data on dermal penetration and long-term wrinkle reduction remain conflicting: large HA molecules (>50 kDa) do not penetrate the stratum corneum. Low-molecular-weight fractions (<50 kDa) penetrate better but may cause irritation at high concentrations.

  • Papakonstantinou E et al. Dermatoendocrinol. 2012;4(3):253-258.

Injectable

A

Proven efficacy. Two or more independent RCTs with instrumental endpoints.

Cross-linked hyaluronic acid dermal fillers are the gold standard for contouring and biorevitalization. Multicenter clinical trials confirm efficacy and safety for wrinkle correction, volume restoration, and skin texture improvement.

  • Beasley KL et al. Dermatol Surg. 2009;35(Suppl 2):1642-1646.
  • Sundaram H et al. Plast Reconstr Surg. 2015;136(5 Suppl):139S-148S.

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Safe

Skin types

Suitable for

OilyCombinationSensitiveNormalDry

Combinations with other ingredients

Works well with

CeramidesЦерамиды

Hyaluronic acid pulls water, ceramides hold it in the barrier. A baseline moisturizing combination.

NiacinamideНиацинамид

Safe pair for most routines. Niacinamide strengthens the barrier, hyaluronic acid retains water in the stratum corneum.

Frequently asked questions

Is Hyaluronic Acid safe during pregnancy?

Hyaluronic Acid is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.

What skin types is Hyaluronic Acid for?

Hyaluronic Acid suits: oily, combination, sensitive, normal, dry.