Polydeoxyribonucleotide (PDRN)

INCI: Polydeoxyribonucleotide

Salmon DNA fragments with molecular weight 50–1500 kDa. Activate purinergic receptors, stimulating angiogenesis and regeneration. Topical application is limited by molecular size.

Anti-agingSoothing

Evidence by route

Topical application

Very weak or conflicting data.

Topical application has no clinically confirmed efficacy due to the inability of these large molecules to cross the epidermal barrier. PDRN creams may provide surface moisturization as formula excipients, but not through specific PDRN activity.

Injectable

Limited evidence. One RCT or several controlled studies with limitations.

Intradermal PDRN injections for photoaging and atrophic scars are supported by several RCTs and prospective studies. Improvements in skin hydration, tone, and dermal density have been demonstrated. Allergic potential is minimal – salmon protein is absent in purified formulations.

Lee JH et al. J Cosmet Laser Ther. 2016;18(4):235-238.
Guo C et al. J Cosmet Dermatol. 2022;21(6):2489-2498.

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Unknown

Skin types

Suitable for

NormalDrySensitiveCombination

Frequently asked questions

Is Polydeoxyribonucleotide (PDRN) safe during pregnancy?

Safety data for Polydeoxyribonucleotide (PDRN) during pregnancy is insufficient. Best avoided when in doubt.

What skin types is Polydeoxyribonucleotide (PDRN) for?

Polydeoxyribonucleotide (PDRN) suits: normal, dry, sensitive, combination.