Chlorphenesin

Evidence by route

About this ingredient

Chlorphenesin is a synthetic compound with antimicrobial and antifungal action. Used as a preservative booster in cosmetics – enhances main preservatives (phenoxyethanol, organic acids) but is not used as a sole preservative. Where applied. Creams, lotions, serums, emulsions (concentration 0.15-0.3%, EU regulatory limit). In Spain – in mass brands CeraVe, La Roche-Posay, Vichy, Bioderma as part of the preservation system. Mechanism. Active mainly against fungi (Candida, Aspergillus) and Gram-positive bacteria. Less effective against Gram-negatives (Pseudomonas) and spore-formers. Used paired with phenoxyethanol or ethylhexylglycerin to cover the full microflora spectrum. Evidence base. A functional ingredient. No direct clinical skin efficacy. Role: prevent microbial product contamination during use. Safety. CIR confirmed safety up to 0.3% in leave-on and 0.5% in rinse-off products. SCCS in 2018 issued a warning: chlorphenesin in baby cosmetics (under 6 months) is restricted due to theoretical neurotoxicity risk under high systemic absorption. Result: mandatory labeling for infant products. Infant controversy. Since 2018 the EU bans chlorphenesin in leave-on cosmetics for children under 3 years. On adult and adolescent skin – safe. Allergic reactions are rare (0.1-0.3% per EPIA 2020). Pregnancy and lactation – use with caution. Topically at cosmetic concentrations systemic absorption is minimal, fetal risk is theoretical. For the nipple area during breastfeeding pick chlorphenesin-free products (e.g. Bepanthen with provitamin B5). Suitable for. Universal for adults. Not for infant cosmetics under 3 years (EU ban).

Tolerability and safety

Skin types

Frequently asked questions