Cucurbita Pepo Seed Extract

Tolerability and safety

Irritation potential

Low

Allergen risk

Low

Pregnancy

Safe

Suitable for

Oily, Combination, Normal

Use with caution

Sensitive

About this ingredient

Cucurbita Pepo Seed Extract is derived from the seeds of common pumpkin Cucurbita pepo. Contains phytosterols (β-sitosterol, cucurbitol), zinc, selenium, tocopherols, unsaturated fatty acids. Mechanism. In vitro phytosterols show antiandrogenic activity – they inhibit 5α-reductase, the enzyme converting testosterone into dihydrotestosterone (DHT). Zinc is a cofactor for dozens of enzymes, including those regulating sebum. Manufacturers market the extract for oily and acne-prone skin and for scalp care (androgenetic hair loss). Where applied. Serums and creams for oily and combination skin, products against seborrheic dermatitis, antiandrogen-positioned hair shampoos and tonics. In Spain – Aromatica Pumpkin, niche hair brands Pilexil, Frenadol, in anti-hair-loss shampoos. Evidence base. Topical clinical data are limited. Oral pumpkin seed oil 400 mg/day in the Cho 2014 RCT reduced hair loss in men with androgenetic alopecia over 24 weeks. Topical data are mostly in vitro on 5α-reductase. No direct confirmation of clinical efficacy on skin and hair from topical use. Safety. CIR has not issued a direct evaluation, but the cucurbit family is generally safe topically. Allergic reactions are rare. Pregnancy and lactation – safe at standard cosmetic concentrations. Oral antiandrogen-positioned supplements during pregnancy should be used cautiously. Best suited to: oily and combination skin, scalp products for oily tendency. Not the main active for acne or hair loss – a marketing-driven active with a limited evidence base.

Frequently asked questions