Methylated sorbitol derivative – a highly effective solvent and penetration enhancer. Increases penetration of actives into the stratum corneum. Pregnancy-safe.
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Functional solvent and penetration enhancer. Safety confirmed by CIR.
Dimethyl Isosorbide is a synthetic isosorbide derivative. INCI: Dimethyl Isosorbide. A clear liquid miscible with water and oils. In cosmetics it works as a solvent and penetration enhancer. It dissolves hard-to-dissolve actives (retinol, salicylic acid, hydroquinone) and helps them penetrate the stratum corneum. Often used in peptide and vitamin C serums. Use levels run from 1 to 10%. Pregnancy safety. CIR rates the safety profile as acceptable. Skin profile. Low irritation potential. Non-comedogenic. Suitable for all skin types. No active effects – a functional component.
Irritation potential
LowAllergen risk
LowPregnancy
SafeSuitable for
Use with caution
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Dimethyl Isosorbide is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Dimethyl Isosorbide suits: normal, dry, combination, oily. Use with caution in: sensitive.
Methylated sorbitol derivative – a highly effective solvent and penetration enhancer.
On the Fulton scale 0/5 – non-comedogenic. For acne-prone skin, a rating of 3 or higher suggests choosing an alternative.
The INCI name is Dimethyl Isosorbide. It may also appear as: DMI, диметил изосорбид.
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