Iodopropynyl Butylcarbamate
Iodine-containing preservative with strong antifungal action. Works at low concentrations but triggers sensitization.
Evidence by route
Topical application
SCCS limits it to small concentrations and forbids use in children's cosmetics. The iodine structure creates risk for people with thyroid pathology.
How to read tiers A–F
- CWeak evidence. In vitro data, open-label studies, or expert consensus
Tolerability and safety
- Irritation potential
- Medium
- Allergen risk
- Moderate
- Pregnancy
- Caution
- Use with caution
- Sensitive
About this ingredient
Iodopropynyl Butylcarbamate (IPBC) is a synthetic preservative with strong antifungal action. Contains an iodine atom in the active part of the molecule. In cosmetic use since the 1990s as an alternative to parabens and formaldehyde-releasers. Mechanism. Suppresses fungal growth (especially Aspergillus and Candida) and bacteria to a lesser extent. Works at very low concentrations – 0.01-0.1%. Where applied. Shampoos, conditioners, hand creams, body lotions, shaving products, antiperspirants (0.01-0.1%). EU permits up to 0.02% in leave-on and 0.1% in rinse-off (Regulation 1223/2009 Annex V). Banned in products for children under 3 and in spray forms. In Spain in Garnier, L'Oréal Paris formulas, men's shaving products. Allergy. Since the 2000s among the top ten contact allergens in cosmetics. IVDK data: sensitization in 1.5-3% of dermatitis patients. ESCD keeps it in the standard patch-test panel. Cross-reactivity with other carbamates is possible but rare. Safety. CIR rated IPBC safe at cosmetic concentrations with the listed restrictions (2008, re-evaluated 2018). EU SCCS confirmed safety. Systemic absorption through skin is minimal, but the iodine content prompts discussion in patients with thyroid disease – no proven clinical significance for topical use. Pregnancy – topical use at cosmetic concentrations is acceptable, but prolonged large-surface use is best avoided due to iodine and a formal classification as a "possible category 2 reproductive toxin" (CLP Regulation). Lactation – use with caution, especially near the areola. Alternatives: phenoxyethanol, benzyl alcohol.
Frequently asked questions
Is Iodopropynyl Butylcarbamate safe during pregnancy?
Iodopropynyl Butylcarbamate should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Iodopropynyl Butylcarbamate for?
Use with caution in: sensitive.
Can Iodopropynyl Butylcarbamate irritate the skin?
Iodopropynyl Butylcarbamate has moderate irritation potential. Sensitive skin may show a transient reaction that usually settles with adaptation.
What is Iodopropynyl Butylcarbamate and what does it do in cosmetics?
Iodine-containing preservative with strong antifungal action.
What's the INCI name for Iodopropynyl Butylcarbamate?
The INCI name is Iodopropynyl Butylcarbamate.
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