Physalis Angulata Extract
Tropical groundcherry extract – a Solanaceae plant. Contains withasteroids (physalins) and alkaloids. Marketed as anti-inflammatory. No direct human RCTs, data come from Latin American ethnopharmacology. Caution with Solanaceae allergies.
Evidence by route
Topical application
Plant extract with no independent RCTs. Physalins are active steroid molecules in vitro, systemic safety profile is poorly studied.
- CIR Cosmetic Ingredient Review safety assessment.
How to read tiers A–F
- DNo data, or very weak or conflicting data
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Moderate
- Pregnancy
- Avoid
- Suitable for
- Normal, Oily, Combination
- Use with caution
- Sensitive
About this ingredient
Physalis Angulata Extract is a Solanaceae plant from tropical Latin America and Africa. Contains withasteroids (physalins A, B, F), flavonoids, alkaloids. Where applied. Marketed as an anti-inflammatory component in natural lines, serums, problem-skin products (0.1-1%). Rare in Spanish and European formulas. Evidence base. Data come from Latin American ethnopharmacology (Brazil 2018). In vitro shows anti-inflammatory activity of physalins via NF-κB inhibition. No topical human RCTs. Safety. The plant contains tropane alkaloids (related to atropine). Systemic high-dose ingestion has shown neurotoxic effects. At cosmetic concentrations through intact skin, systemic absorption is minimal. Contact dermatitis possible in patients with Solanaceae allergy (potato, tomato, eggplant, pepper). Pregnancy and lactation – avoid. Solanaceae plants taken systemically have been linked to pregnancy-loss risk. Topical use at cosmetic concentrations – insufficient data; avoidance recommended. Alternatives for sensitive skin – niacinamide, centella, adenosine.
Frequently asked questions
Is Physalis Angulata Extract safe during pregnancy?
Physalis Angulata Extract is not recommended during pregnancy. Consider an alternative from the same category.
What skin types is Physalis Angulata Extract for?
Physalis Angulata Extract suits: normal, oily, combination. Use with caution in: sensitive.
What is Physalis Angulata Extract and what does it do in cosmetics?
Tropical groundcherry extract – a Solanaceae plant.
What's the INCI name for Physalis Angulata Extract?
The INCI name is Physalis Angulata Extract. It may also appear as: Cutleaf Groundcherry Extract.
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