Sulfur
Elemental sulfur in colloidal form. One of the oldest topical anti-acne ingredients. Disrupts hyperkeratosis at follicular openings and provides mild keratolytic and antibacterial effects. Used for acne and seborrheic dermatitis. The characteristic smell limits patient acceptability.
Evidence by route
Topical application
BLimited evidence. One RCT or several controlled studies with limitations.
Topical sulfur 2-10% is included in AAD 2024 guidelines as an option for mild acne and rosacea (combined with sulfacetamide). The effect is modest compared with adapalene or benzoyl peroxide, but it is well tolerated in pregnancy.
- Zaenglein AL et al. J Am Acad Dermatol. 2016;74(5):945-973.
Tolerability and safety
Irritation potential
MediumAllergen risk
LowPregnancy
SafeSkin types
Suitable for
Use with caution
Frequently asked questions
Is Sulfur safe during pregnancy?
Sulfur is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
What skin types is Sulfur for?
Sulfur suits: oily, combination. Use with caution in: sensitive, dry.
Can Sulfur irritate the skin?
Sulfur has moderate irritation potential. Sensitive skin may show a transient reaction that usually settles with adaptation.