Synthetic 13-amino-acid peptide. The manufacturer claims stimulation of collagen and elastin synthesis, with rejuvenating and anti-ageing effects. Belongs to the 'signalling' peptide class. Independent clinical studies with efficacy comparable to retinol or vitamin C are not available. Positioned as a retinoid alternative for sensitive skin.
Topical application
DVery weak or conflicting data.
Signalling peptides as a class show modest effects in a few controlled studies. Specific clinical data for Tridecapeptide-1 with adequate methodology are scarce. The primary evidence base is from the manufacturer; methodology is not in the open literature.
Tridecapeptide-1 is a synthetic 13-amino-acid peptide. It entered cosmetics in the 2010s with marketing positioning as a 'retinol alternative for sensitive skin'. Under the Reed (2016) classification it belongs to the signalling peptide group. Mechanism – as claimed. The manufacturer describes binding to fibroblast receptors and stimulation of type I procollagen and elastin synthesis. In vitro work on isolated keratinocytes shows weak induction of collagen gene expression, but RCT-level clinical proof is missing. Where applied. Premium anti-ageing serums, eye-area products, ampoules for mature skin. In Spain it shows up in Sesderma and Skeyndor lines and in Mesoestetic Energy C specialty products. Use levels in finished formulas: 0.01-0.1%. Evidence base. No independent RCT-level clinical studies of tridecapeptide-1 monotherapy have been published. Head-to-head comparisons with retinol or vitamin C have not been done. All data come from internal ingredient-supplier reports or brand-funded marketing studies. Safety. As a class, peptides tolerate well: the molecules are large (1-2 kDa), don't penetrate beyond the epidermis, don't sensitise. Non-comedogenic. Not photosensitising. Pregnancy and lactation – formally safe (no systemic absorption), but pregnant patients rarely get peptides recommended deliberately because evidence is modest and benefit unclear. Better to pick niacinamide or hyaluronic acid. Suited for. Mature skin with light wrinkles, sensitive skin that does not tolerate retinoids. Realistic expectation: the effect is weaker than retinol 0.3% and vitamin C 10-15%, closer to premium hydration.
Irritation potential
LowAllergen risk
LowPregnancy
SafeThe Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Tridecapeptide-1 is considered safe during pregnancy at typical cosmetic concentrations. Systemic absorption through the skin is minimal.
Tridecapeptide-1 suits: normal, dry, combination, sensitive.
Synthetic 13-amino-acid peptide.
The INCI name is Tridecapeptide-1. It may also appear as: sh-Decapeptide-9, Тридекапептид-1, ТридекапептидOne.
Published: · updated:
Suitable for