Troxerutin
Semi-synthetic flavonoid, derivative of rutin. In pharmacology used for vein tonic products (Troxevasin). In cosmetics marketed as a capillary-strengthening ingredient for the eye area – against dark circles and puffiness.
Evidence by route
Topical application
Vascular-strengthening effect is proven for oral use (chronic venous insufficiency). Topical effects on dark eye circles are confirmed only by small uncontrolled studies.
- Martinez-Zapata MJ et al. Phlebotonics for venous insufficiency. Cochrane Database Syst Rev. 2020;(11):CD003229.. PMID 33141449
How to read tiers A–F
- BLimited evidence. One RCT or several controlled studies with limitations
Tolerability and safety
- Irritation potential
- Low
- Allergen risk
- Low
- Pregnancy
- Caution
- Suitable for
- Normal, Dry, Combination
- Use with caution
- Sensitive
About this ingredient
Troxerutin (Trihydroxyethylrutin) is a semi-synthetic flavonoid derived from rutin (a flavonoid from buckwheat and Sophora). In pharmacology it is used for chronic venous insufficiency and haemorrhoids (Troxevasin, Venoruton). In cosmetics – claimed capillary strengthening. Mechanism. Lowers capillary permeability, inhibits hyaluronidase and elastase. In eye-area skin capillaries – claimed reduction in visibility of venous congestion (dark circles) and puffiness. Antioxidant effects in vitro. Where applied. Eye creams and serums, products for dark circles and puffiness, products for couperose skin. In Spain – in Sesderma Factor G Renew, Mesoestetic Eye Contour, Endocare Tensage lines. Evidence base. Oral troxerutin in chronic venous insufficiency has moderate evidence (Cochrane 2015: minor symptom improvement). Topical use in cosmetics – RCTs with 'dark circles' as an endpoint are absent. The effect is attributed to oral flavonoid therapy, not topical use. Safety. Sensitises rarely, non-comedogenic. Rare photodermatitis and contact allergy possible (1-2% of patients). Pregnancy – use with caution. Oral troxerutin in the first trimester is not recommended (theoretical teratogenic risk per AEMPS). Topical at cosmetic concentrations is minimally absorbed, but pregnant women with dark circles should pick caffeine and cooling instead. Realistic expectations. Eye dark circles have three causes: pigmentary (hereditary), vascular (visible veins), and tear-trough shadows (anatomy). Topical troxerutin works only on the vascular component, and only on in vitro grounds. Best treatments are filler correction, vascular laser, and concealer makeup.
Frequently asked questions
Is Troxerutin safe during pregnancy?
Troxerutin should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
What skin types is Troxerutin for?
Troxerutin suits: normal, dry, combination. Use with caution in: sensitive.
What is Troxerutin and what does it do in cosmetics?
Semi-synthetic flavonoid, derivative of rutin.
What's the INCI name for Troxerutin?
The INCI name is Troxerutin. It may also appear as: Trihydroxyethylrutin.
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