Fermentation product of the soil bacterium Vitreoscilla. Positioned as a skin oxygenation ingredient; clinical evidence is weak.
Topical application
DVery weak or conflicting data.
Marketing biotech ingredient. Clinical evidence for claimed skin effects is very limited; the 'skin oxygenation' mechanism is implausible.
Vitreoscilla Ferment is the product of fermentation of non-pathogenic Gram-negative bacteria of the genus Vitreoscilla, found in soil and fresh water. It contains bacterial hemoglobin (VHb), a protein able to bind and transport oxygen at low partial pressure. In cosmetics, it is used in anti-aging creams, recovery serums, and products for dull or tired skin at 1–5%. Claimed mechanism: enhanced cellular respiration, activation of mitochondrial activity in keratinocytes and fibroblasts, and support for regeneration under hypoxia (urban environment, smoking, sleep deprivation). Clinical evidence is limited – most studies have been conducted by manufacturers (in vitro and small open-label in vivo); independent randomized controlled trials are lacking. Marketing positioning as a 'skin breathing' ingredient is not rigorously supported by science. Safe to use, non-irritating and non-allergenic. Suitable for all skin types and unrestricted in pregnancy and breastfeeding. The effect is more moisturizing and mildly antioxidant than strongly anti-aging – best used as a supporting ingredient rather than a primary active.
Irritation potential
LowAllergen risk
LowPregnancy
CautionSuitable for
The Evigrade extension adds an evidence panel to Wildberries, Goldapple, Letu, iHerb, Sephora and 12 more stores. This ingredient and every other one in the product show evidence-tier, allergen risk and pregnancy/lactation flags at a glance.
Vitreoscilla Ferment should be used with caution during pregnancy. Consulting a dermatologist or OB-GYN is advisable.
Vitreoscilla Ferment suits: normal, dry, oily, combination. Use with caution in: sensitive.
Fermentation product of the soil bacterium Vitreoscilla.
The INCI name is Vitreoscilla Ferment. It may also appear as: Vitreoscilla Ferment Extract.
Published: · updated:
Use with caution