MajorAntiplatelet agents (low dose) / NSAIDs (analgesic dose)×Non-steroidal anti-inflammatory drugs (NSAIDs)
Updated · Methodology
Mechanism
Ibuprofen reversibly binds platelet COX-1 and blocks aspirin's access to its irreversible acetylation site. Aspirin's antiplatelet effect is lost – cardiovascular event risk.
Symptoms
No symptoms – risk is loss of cardioprotection.
Management
If ibuprofen needed – take 8 hours BEFORE or 30 minutes AFTER aspirin. Alternative in cardiovascular risk – paracetamol.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: FDA safety communication: ibuprofen-aspirin (2006)
- AEMPS: Ficha técnica: Ibuprofeno (nº registro 63597), sección 4.5 (2025)– AEMPS, CIMA, nº registro 63597, revisión 04/2025, sección 4.5