ModerateCalcium channel blockers (dihydropyridines)×Non-steroidal anti-inflammatory drugs (NSAIDs)
Updated · Methodology
Mechanism
NSAIDs weaken amlodipine's antihypertensive effect via prostaglandin suppression. Diclofenac additionally raises cardiovascular risk.
Symptoms
Gradual blood pressure rise 1–2 weeks after starting the NSAID. In chronic kidney disease: risk of fluid retention and oedema.
Management
Avoid prolonged diclofenac use. For acute pain: short course (5–7 days) with pantoprazole cover. For chronic analgesia: paracetamol, celecoxib, or topical NSAIDs.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- ESH: 2023 ESH Guidelines for the management of arterial hypertension (2023)
- AEMPS: Ficha técnica: Diclofenaco (nº registro 62161), sección 4.5 (2025)– AEMPS, CIMA, nº registro 62161, revisión 08/2025, sección 4.5