ModerateSelective beta-adrenergic blockers×Loop diuretics
Updated · Methodology
Mechanism
Standard combination in heart failure and hypertension. Additive hypotensive effect; furosemide causes hypokalaemia, amplifying arrhythmia risk with concomitant QT-prolonging drugs.
Symptoms
Lower blood pressure, postural dizziness, fatigue. Older patients: fall risk. With additional antihypertensives: bradycardia (pulse below 60/min).
Management
Standard combination. Check potassium and magnesium every 1–3 months. If potassium drops below 4.0 mmol/L, add a potassium-sparing diuretic (spironolactone) or potassium supplement. Check blood pressure and pulse 1–2 weeks after start.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- ESC: ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure (2021)– McDonagh TA et al. Eur Heart J 2021;42:3599-3726