ModerateSelective beta-adrenergic blockers×Non-steroidal anti-inflammatory drugs (NSAIDs)
Updated · Methodology
Mechanism
Similar to bisoprolol + ketorolac. Ibuprofen weakens the antihypertensive effect of the beta-blocker via renal prostaglandin blockade.
Symptoms
Gradual blood pressure rise 1–2 weeks after starting the NSAID. In chronic kidney disease: risk of fluid retention and oedema.
Management
For short ibuprofen courses (5–7 days), monitor blood pressure. For chronic analgesia: switch to paracetamol, celecoxib (with PPI cover), or topical NSAIDs.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Bisoprolol tablet (Micro Labs Limited) – Prescribing Information (2016)– ; DailyMed setid c3ee566c-74c4-45f4-a947-526a7313e326
- AEMPS: Ficha técnica: Ibuprofeno (nº registro 63597), sección 4.5 (2025)– AEMPS, CIMA, nº registro 63597, revisión 04/2025, sección 4.5
- AEMPS: Ficha técnica: Bisoprolol (nº registro 78903), sección 4.5 (2026)– AEMPS, CIMA, nº registro 78903, revisión 05/2026, sección 4.5