ModerateSelective beta-adrenergic blockers×Non-steroidal anti-inflammatory drugs (NSAIDs)
Updated · Methodology
Mechanism
NSAIDs weaken the antihypertensive effect of beta-blockers via prostaglandin-dependent renal regulation (natriuresis). Ketorolac is the most potent NSAID.
Symptoms
Gradual blood pressure rise 1–2 weeks after starting the NSAID. In chronic kidney disease: risk of fluid retention and oedema.
Management
Ketorolac courses are limited to 5 days. Check blood pressure in the first days. In borderline hypertension, temporarily increase bisoprolol. For chronic analgesia: paracetamol or a short opioid course.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Ketorolac tromethamine tablet (Amerisyn LLC) – Prescribing Information (2013)– ; DailyMed setid 5734e81e-2471-1314-e063-6294a90ac9fe
- AEMPS: Ficha técnica: Bisoprolol (nº registro 78903), sección 4.5 (2026)– AEMPS, CIMA, nº registro 78903, revisión 05/2026, sección 4.5
- AEMPS: Ficha técnica: Ketorolaco (nº registro 70105), sección 4.5 (2026)– AEMPS, CIMA, nº registro 70105, revisión 01/2026, sección 4.5