ModerateAnxiolytics. Benzodiazepine derivatives×Second-generation antihistamines
Updated · Methodology
Mechanism
Loratadine rarely causes sedation at standard doses. With diazepam, mild additive CNS depression is possible, especially in older patients.
Symptoms
Sedation, fatigue, slowed reactions, impaired coordination. In older patients: fall and fracture risk. Driving and operating machinery: accident risk.
Management
On standard loratadine (10 mg/day) with intermittent diazepam (e.g. for anxiety), no adjustment needed. In older patients and on long-term benzodiazepine therapy, watch for sedation signs. For anxiety disorders, consider alternatives to diazepam: buspirone or CBT.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- FDA: Tylenol 8 HR Arthritis Pain (acetaminophen) – label (2020)– ; DailyMed setid 3af22fc8-e4e0-4863-8696-6bc1257047cb