MajorNon-steroidal anti-inflammatory drugs (NSAIDs)×Selective serotonin reuptake inhibitors (SSRIs)
Updated · Methodology
Mechanism
SSRIs reduce platelet serotonin uptake – impaired aggregation. With NSAIDs (antiplatelet + GI mucosal damage) – significant GI bleeding risk increase.
Symptoms
GI bleeding, especially in patients over 60 with prior peptic ulcer disease.
Management
In high-risk patients – PPI gastroprotection. Alternative analgesic – paracetamol.
Check the full regimen, not just this pair
Opens the checker with these two drugs prefilled. Add the rest of the regimen and recompute additive risks.
Summary of a multi-drug list →
Medicine list: everything you take in one place →
Sources
- DailyMed: Sertraline: FDA prescribing information, Drug Interactions section (DailyMed) (2024)
- AEMPS: Ficha técnica: Sertralina (nº registro 66057), sección 4.4 (2025)– AEMPS, CIMA, nº registro 66057, revisión 08/2025, sección 4.4
- AEMPS: Ficha técnica: Ibuprofeno (nº registro 63597), sección 4.4 (2025)– AEMPS, CIMA, nº registro 63597, revisión 04/2025, sección 4.4