Metodología y principios editoriales
Cómo Evigrade evalúa medicamentos y componentes cosméticos. Metodología, posición legal, derecho de réplica.
What Evigrade publishes
Evigrade publica revisiones analíticas y opiniones editoriales basadas en guías clínicas internacionales públicas, ensayos clínicos aleatorizados y metaanálisis.
How tiers are assigned
Las calificaciones de evidencia (niveles A, B, C, D, F) las asigna el consejo editorial siguiendo una metodología pública y reproducible, y se revisan al surgir nuevos datos.
- Tier A – confirmed by ≥2 independent RCTs with clinical endpoints.
- Tier B – one RCT or several controlled studies with limitations.
- Tier C – conflicting data, in vitro or open-label studies.
- Tier D – very weak or conflicting evidence base.
- Tier F – no evidence of efficacy, or proven inefficacy.
The methodology follows the GRADE approach (Grading of Recommendations Assessment, Development and Evaluation) and the Oxford Centre for Evidence-Based Medicine Levels of Evidence.
Legal nature of the content
El contenido presenta opiniones editoriales, no afirmaciones de hecho, y no busca publicidad o antipublicidad de fabricantes concretos. La calificación aplica a la denominación común internacional del medicamento, no a una marca particular.
Evaluative opinions based on public sources are not subject to factual refutation. The editorial evidence rating reflects the editorial board's opinion grounded in publicly available guidelines and studies; it does not contain statements of fact susceptible to verification.
Right of reply
Los fabricantes y titulares de derechos pueden enviar una respuesta motivada a editorial@evigrade.com. La redacción la publica sin editar en un plazo de 14 días hábiles.
A reply must include references to published scientific data. The editorial team reserves the right to append its own commentary without modifying the text of the reply itself.
Corrections and re-evaluation
The editorial team re-evaluates tiers as new randomized controlled trials, meta-analyses, or updated clinical guidelines from international specialist associations appear. Each card displays the date of the last review.
What the tier rates
Ratings apply to the international nonproprietary drug name and a specific indication, not to brands. The same INN receives different tiers for different indications. A tier F for one indication does not imply inefficacy for other indications.
Conflicts of interest
Evigrade is an independent encyclopedia. The editorial team has no direct commercial ties to drug or cosmetics manufacturers. Tier ratings do not depend on marketplace availability, manufacturer advertising budgets, or partnership requests.
Medical disclaimer
Este contenido no reemplaza la consulta con un médico colegiado.
Contact the editorial team
General inquiries: editorial@evigrade.com