Systemic fungal infection

Fungal infection with internal organ involvement (candidaemia, invasive aspergillosis, cryptococcal meningitis, mucormycosis). Occurs in immunocompromised patients and during prolonged hospital stays.

ICD-10 B491 drug

Also known as: Invasive mycosis, Candidaemia

Drugs used for this condition

AAmphotericin BFirst line · Polyene systemic antifungalAmphotericin B is first-line antifungal for severe systemic mycoses: cryptococcal meningitis, mucormycosis, severe invasive candidiasis and aspergillosis, visceral leishmaniasis. IDSA 2024 and SEIMC recommend liposomal formulation (AmBisome) as standard due to lower nephrotoxicity than deoxycholate Fungizone. With long-term use – check creatinine, potassium and magnesium every other day for the first 2 weeks.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit