Barrett esophagus

Replacement of the stratified squamous epithelium of the distal esophagus with intestinal-type columnar epithelium due to chronic acid reflux. A premalignant condition requiring endoscopic surveillance.

ICD-10 K22.71 drug

Also known as: Barrett's esophagus, Columnar-lined esophagus

Drugs used for this condition

BEsomeprazoleFirst line · Drugs for peptic ulcer and GORD. Proton pump inhibitorsIn Barrett esophagus, PPIs are prescribed lifelong to suppress acid reflux and reduce metaplasia progression. ACG 2022 supports continuous PPI therapy in confirmed Barrett esophagus. Adenocarcinoma prevention data are observational; randomized evidence of cancer risk reduction is lacking, but reflux control remains standard practice.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit