Chronic pancreatitis

Progressive inflammatory disease of the pancreas with parenchymal replacement by fibrous tissue and loss of exocrine and endocrine functions. Main causes: alcohol, genetic factors, ductal obstruction, autoimmune mechanisms.

ICD-10 K86.11 drug

Also known as: CP

Drugs used for this condition

APancreatinFirst line · Digestives. Multienzyme preparationsIn chronic pancreatitis with confirmed exocrine insufficiency (fecal elastase < 200 µg/g or clinically evident steatorrhea), pancreatin is a mandatory component of therapy. Without replacement, patients develop weight loss, osteoporosis and fat-soluble vitamin deficiency. The standard starting dose is 25 000–40 000 lipase units per main meal.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit