Iodine deficiency disorders
Conditions caused by insufficient dietary iodine intake: endemic goitre, hypothyroidism, neuropsychological development disorders in children. Russia is a region of mild-to-moderate iodine endemicity. WHO recommends universal salt iodisation as foundational prevention.
ICD-10 E012 drugs
Also known as: IDD, Endemic goitre, Iodine deficiency
Drugs used for this condition
- AIodine (umbrella: potassium iodide, kelp / Fucus vesiculosus)First line · Trace element; substrate of thyroid hormone synthesisPrevention and treatment of iodine deficiency disorders: endemic goitre, deficiency hypothyroidism, childhood cretinism. WHO 2007 and 2014 recommend universal salt iodisation and additional 150 mcg/day in adults in endemic regions. Russia and parts of Spain are moderately iodine-deficient; routine iodine prophylaxis is reasonable in Moscow, the Ural and Siberian regions and in Castile and León. AEMPS approves Yoduk and Yodocefol for this purpose. Potassium iodide is the drug of choice; iHerb kelp is unsuitable for routine prevention due to dose variability.
- APotassium iodideFirst line · Iodine therapy for thyroid functionPotassium iodide 100–200 µg daily is first-line prevention and treatment of iodine deficiency disorders. WHO recommends universal salt iodisation as foundational population prevention. Individual supplementation is indicated in children, adolescents, and people not consuming iodised salt in regions of mild-to-moderate iodine endemicity. Russian Ministry of Health guidelines include potassium iodide as a required component of IDD prevention.
How to read tiers A–F
Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.
- AStrong evidence – first or second line in international guidelines
- BRecommended in selected cases
- CStudy data contradict each other
- DBenefit not proven, no documented harm
- FDocumented harm, or risk without benefit