Longevity and anti-aging biohacking (marketing category)

Marketing category for substances sold as «life extension», «sirtuin activation», «telomere protection» and «cellular rejuvenation». This includes resveratrol, NMN, NR, spermidine, fisetin, quercetin, saffron and dozens of other supplements. EFSA has approved no longevity claim. Most data come from yeast, nematodes and mice. Human RCTs with mortality or lifespan endpoints do not exist. NIH and USPSTF 2022 hold that supplements in healthy adults do not lower mortality or slow biological aging. Real proven longevity factors: smoking cessation, blood-pressure and glucose control, physical activity, a Mediterranean diet pattern and adequate sleep.

1 drug

Also known as: Longevity molecule, Anti-aging supplement, Life-extension

Marketing claims without evidence base

The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.

DSaffron (Crocus sativus stigma extract)Not recommended · Herbal antidepressant supplement, standardised affron® and Safr'Inside® extractsSaffron is a spice made from the stigmas of the Crocus sativus flower; the extract is marketed as a supplement for longevity and slowing aging. Its benefit for this use has not been proven – there's no solid evidence behind an anti-age effect or any impact on lifespan. Aging responds to other, well-tested things: sun protection, not smoking, sleep, movement and diet.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit