Edema in nephrotic syndrome

Severe edema in the context of massive proteinuria (> 3.5 g/day), hypoalbuminemia, and hyperlipidemia. Loop diuretics are used in high doses, often combined with a thiazide diuretic and sodium restriction.

ICD-10 N041 drug

Also known as: Nephrotic edema

Drugs used for this condition

AFurosemideFirst line · Loop diureticsLoop diuretics are the cornerstone of symptomatic therapy for edematous syndromes in nephrotic syndrome and CKD per KDIGO. In severe hypoalbuminemia, combination with albumin infusion may be required to expand intravascular volume and deliver the drug to its site of action. In eGFR below 30, higher doses (80–160 mg or more) are needed.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit