Intermittent claudication in peripheral artery disease
Exertional ischaemic leg pain that resolves at rest. Management centres on supervised exercise, smoking cessation, statin, and antiplatelet therapy. Cilostazol is discussed for inadequate response. Ginkgo biloba is not considered in current guidelines (ESC 2024, AHA/ACC 2024).
ICD-10 I70.21 drug
Also known as: Claudication
Marketing claims without evidence base
The drug is promoted for these uses outside international guidelines. Each entry below is analyzed against AEMPS, FDA, EMA, Cochrane and major RCTs.
How to read tiers A–F
Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.
- AStrong evidence – first or second line in international guidelines
- BRecommended in selected cases
- CStudy data contradict each other
- DBenefit not proven, no documented harm
- FDocumented harm, or risk without benefit