Post-thyroidectomy state

Lifelong levothyroxine replacement after total or subtotal thyroidectomy for nodular goiter, thyrotoxicosis, or cancer.

ICD-10 E89.01 drug

Also known as: Post-surgical hypothyroidism

Drugs used for this condition

ALevothyroxine sodiumFirst line · Thyroid hormonesLifelong replacement is required after total thyroidectomy. In thyroid cancer, TSH suppression to below 0.1 mU/L is the target in high-risk patients (per AJCC and ATA staging) and 0.1–0.5 mU/L in intermediate risk. After subtotal resection for benign disease, the goal is euthyroidism with the same TSH target as for hypothyroidism.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit