Pre-eclampsia prevention in low dietary calcium intake

Calcium supplementation of 1.5–2 g elemental calcium daily in pregnant women with dietary intake below 600 mg daily reduces pre-eclampsia risk. WHO 2020 recommends this intervention in populations with low baseline calcium intake.

ICD-10 O14.91 drug

Also known as: Pre-eclampsia prevention with low calcium intake

Drugs used for this condition

BCalcium (oral salts: carbonate, citrate, lactate, gluconate)Case-by-case decision · Mineral supplements. CalciumIn pregnant women with low dietary calcium intake (less than 600 mg daily), supplementation of 1.5–2 g elemental calcium daily reduces pre-eclampsia risk by about 50% per the 2015 Cochrane meta-analysis. WHO 2020 recommends this intervention in populations with low baseline intake. In women with adequate dietary calcium, the effect is minimal.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit