Staphylococcal prosthetic joint infection

Infection of hip, knee, or shoulder prostheses caused by S. aureus or coagulase-negative staphylococci. Rifampicin as part of combination therapy increases the chance of eradicating biofilm infection.

ICD-10 T84.51 drug

Also known as: Periprosthetic staphylococcal joint infection

Drugs used for this condition

BRifampicinAdd-on therapy · Antituberculous antibioticRifampicin 300–450 mg twice daily is added to base therapy (vancomycin, cefazolin, levofloxacin) in staphylococcal periprosthetic infections after surgical debridement. IDSA 2013 includes rifampicin in DAIR (debridement, antibiotics, implant retention) regimens and for patients with retained prostheses. Its advantage is activity against staphylococcal biofilms. Not used as monotherapy due to rapid selection of resistance.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit