Subclinical hypothyroidism

Elevated TSH with normal T4 and T3 and no overt symptoms. Treatment is individualized by age, TSH level, and comorbidities.

ICD-10 E021 drug

Also known as: Mild thyroid failure

Drugs used for this condition

BLevothyroxine sodiumCase-by-case decision · Thyroid hormonesSubclinical hypothyroidism (TSH 4.5–10 mU/L, normal T4) may be treated selectively. ATA recommends therapy when TSH exceeds 10 mU/L, in patients with TPO antibodies and hypothyroid symptoms, and in women who are pregnant or planning pregnancy. Asymptomatic elderly patients are generally not treated because of iatrogenic thyrotoxicosis risk.

How to read tiers A–F

Evidence tiers belong to the drug-indication pair, not to the drug as a whole: the same substance can be A for one condition and F for another.

AStrong evidence – first or second line in international guidelines
BRecommended in selected cases
CStudy data contradict each other
DBenefit not proven, no documented harm
FDocumented harm, or risk without benefit